Important Safety Information
PRISTIQ® (desvenlafaxine) is a prescription
medication approved for the treatment of major
depressive disorder in adults.
Suicidality and Antidepressant Drugs
Antidepressants increased the risk compared
to placebo of suicidal thinking and behavior
(suicidality) in children, teens, and young adults.
Depression and certain other psychiatric disorders
are themselves associated with increases in
the risk of suicide. Patients of all ages who are
started on antidepressant therapy should be
monitored appropriately and observed closely
for clinical worsening, suicidality, or unusual
changes in behavior. PRISTIQ is not approved
for use in children under
1 8
.
• People taking MAOIs should not take PRISTIQ.
• All patients taking antidepressants should be observed
closely for signs that their condition is getting worse or
that they are becoming suicidal. This is very important
when an antidepressant is started or when the dose is
changed. Patients should be watched for becoming
agitated, irritable, hostile, aggressive, impulsive, or
restless. These symptoms should be reported to the
patient’s healthcare professional right away.
• Tell your healthcare professional about all prescription
and over-the-counter medications you are taking or plan
to take, including:
- Medicines to treat migraines or mood disorders, to avoid
a potentially life-threatening condition
-Aspirin, NSAID pain relievers, or blood thinners
because they may increase the risk of bleeding
• PRISTIQ may cause or make some conditions worse,
so tell your healthcare professional about all your
medical conditions, including if you:
- Have high blood pressure. Your blood pressure
should be controlled before you start taking PRISTIQ
and monitored regularly
- Have heart problems, high cholesterol or triglyceride
levels, or a history of stroke
- Have glaucoma or increased eye pressure
- Have kidney or liver problems
- Have or had mania, bipolar disorder, seizures,
or convulsions
- Have low sodium levels in your blood
-Are nursing, pregnant, or plan to become pregnant
• Discontinuation symptoms may occur when stopping
PRISTIQ, especially when therapy is stopped suddenly.
Talk to your healthcare professional before you stop
taking or reduce the dose of PRISTIQ.
• Until you see how PRISTIQ affects you, be careful
driving a car or operating machinery. Avoid drinking
alcohol while taking PRISTIQ.
• Side effects when taking PRISTIQ 50 mg may
include nausea, dizziness, sweating, constipation,
and decreased appetite.
Please see Brief Summary of
Prescribing Information on next page.
You are encouraged to report negative side
effects of prescription drugs to the FDA.
Visitwww.fda.gov/medwatch, or call 1-800-FDA-1088.
Visit Pristiq.com or call
1
-
8 0 0
-PRISTIQ
If you do not have prescription drug insurance and
need help paying for PRISTIQ, Wyeth may be able
to help. Visit us at www.wyeth.com or call us at
1-800-568-9938 for more information.
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©
2009
, Wyeth Pharmaceuticals Inc., Philadelphia. PA
19101
